When it hurts you just want relief from the pain.

TriVisc® and your doctor are here to help.

Knee pain

What is TriVisc?

TriVisc is a product that is injected into your knees to treat knee pain from joint inflammation and stiffness due to a disease known as osteoarthritis (OA).

TriVisc is from a class of products known as hyaluronic acid, sodium hyaluronate, or hyaluronan (HA), which is also referred to as viscosupplementation therapy. It’s used in a nonsurgical procedure that helps supplement the viscous properties of the fluid in your knee joint. TriVisc is approved for patients who have not adequately responded or have failed to find sufficient relief from simple analgesics, exercise or physical therapy.

How does TriVisc work?

The precise mechanism by which TriVisc works is unknown. The fluid (synovial fluid) in your knee helps to lubricate and cushion the joint during movement. The major component in the synovial fluid is hyaluronic acid, the same active component of TriVisc. One of the early effects of OA is to break down the fluid, making it less effective. It is thought that TriVisc injection helps restore the synovial fluid to a healthier state, thereby reducing the pain of OA.

How is TriVisc administered?

TriVisc is administered by intra-articular injection. Intra-articular means your healthcare professional will insert a needle into the space in your knee joint that contains fluid used for lubrication and cushioning.

How many injections should I receive?

Clinical investigations with TriVisc have demonstrated that three injections one week apart provide optimal pain relief. The effectiveness of less than three injections has not been evaluated. You should discuss this with your doctor. Completion of the full injection treatment course is recommended to achieve the greatest therapeutic benefit.

When can I expect pain relief?

Each patient’s response to TriVisc may vary. Depending on the severity of your OA, degree of pain, and pre-existing medical conditions. In some patients, successful treatment may reduce pain within the first week after treatment begins. However, based upon clinical trials, most patients experience pain relief after their third injection of TriVisc.

How long can I expect the relief to last?

Each patient reacts differently to TriVisc treatment. Three injections given at weekly intervals can provide most patients up to 12 weeks of pain relief. The duration of pain relief you experience may vary.

How safe is TriVisc?

TriVisc was approved for use in the United States in 2017. TriVisc has demonstrated a very favorable safety profile, with over 35 million doses administered worldwide since its first approval, and has been studied in over 30 clinical trials for use in relieving osteoarthritis knee pain.

What should I do after my treatments?

It is recommended that you avoid strenuous activities such as jogging, tennis, and heavy lifting for at least 48 hours after receiving an injection. Your healthcare provider will advise you about the level of activity that is right for you. Most patients are able to maintain their normal daily activities after receiving TriVisc treatment.

Can I take other medications with TriVisc?

Because TriVisc is injected directly into the joint rather than administered systemically, and there are no known drug interactions, you may be able to take other medications with it. TriVisc is not known to interfere with other pain relievers and anti-inflammatory drugs. The safety and effectiveness of the use of TriVisc at the same time as other intra-articular injections, such as steroids, has not been established. Because it is administered locally it is unlikely that you will observe any benefit in joints not specifically injected. You should discuss all of your current medications and vitamin supplements with your physician on a periodic basis.

Are there any reasons why I should not receive TriVisc?

Avoid this product if you have a known hypersensitivity (allergy) to TriVisc or HA products such as rash, itching, hives, flushing, swelling of the face, tongue or throat, and/or difficulty breathing.

Avoid in people with infections or skin diseases in the area of the injection site.

Please see the Full Prescribing Information.

What are the possible side effects?

Some side effects may occur during the use of TriVisc, with symptoms such as knee pain, inflammation, reddening, swelling appearing at the injection site and/or joint pain. Tell your healthcare provider if you experience any side effects after treatment of TriVisc.

Will my insurance cover TriVisc?

Most insurance carriers and Medicare cover TriVisc. The process of obtaining reimbursement varies from plan to plan so talk with your doctor’s office and your insurance provider before you begin treatment to find out if TriVisc is covered.

How do I know if TriVisc is right for me?

Your healthcare provider is the best person to advise you on any course of treatment. TriVisc is approved for the treatment of knee pain due to Osteoarthritis of the knee in patients who do not get enough relief from simple over the counter pain medication or from exercise and physical therapy.

For more Information, please ask your healthcare provider or refer to the Full Prescribing Information for TriVisc.


35 million administrated worldwide.2 †

Determined to be non-inferior to Visco-3®2 and Euflexxa®3 Supported by published clinical data

– TriVisc exhibited improvement in WOMAC, VAS and patient satisfaction compared to baseline4,5